There are eight public school districts in Darke County - Ansonia, Arcanum Butler, Bradford, Franklin Monroe, Greenville, Mississinawa Valley, Tri-Village and Versailles. The Darke County Education Services Center also provides a system of comprehensive pupil services, curriculum leadership, and management services to the county education enterprise. In addition to the public schools in Darke County, there are parachial schools and a Montessori school.

Pre-School programming in cooperation with the Anthony Wayne Mental Retardation and Developmental Disabilities Board provides comprehensive services for disabled children alongside typically developing youngsters. Gifted education is also a county-wide priority.

Vocational education opportunities are available in Darke County. Edison Community College operates a main campus in Piqua and a Darke County Center in Greenville. Two-year associate degree programs in several career fields are offered at Edison as well as transfer credits to many area four-year bachelor degree program colleges and universities.

Indiana University East/Purdue University Programs in Richmond, Indiana, offers 13 certificates and 38 associate and bachelor degree programs in the areas of Natural Science and Mathematics, Behavioral and Social Science, Business and Technology, Humanities and Fine Arts, Education and Nursing. The Ohio Option allows residents of Darke County to enroll at IU East at in-state tuition rates.

Other colleges and universities nearby include Write State University in Dayton and Celina, Sinclair Community College in Dayton, Ball State University in Muncie, Miami University in Oxford, Bowling Green State University, The University of Cincinnati, and The Ohio State University in Columbus.